Sodium hydride → HCID 53902604, compound

HRID 1702892Notes

Reaction equation

HRID 1702892 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:11][C:12](=[O:23])[N:13]([CH3:22])[C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[F:21].[CH3:24][O:25][C:26](=[O:35])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]Br>CN(C=O)C>[CH3:24][O:25][C:26](=[O:35])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][N:11]1[C:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[F:3])=[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[N:13]([CH3:22])[C:12]1=[O:23]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 11107373Methyl 8-bromooctanoateHCID 20525409HCID 20525409, compound

Product 1

HCID 53902604HCID 53902604, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 0.63 of NaH (80% suspension in mineral oil), 5.9 g of 4.5-bis-(2-fluorophenyl)-1-methyl-4-imidazolin-2-one, 40 cc. of DMF, 5.0 g of 8-bromo caprylic methyl ester and 0.63 g of NaJ.

Workup

  1. customThe product is produced

Sources & evidence

ORD record
ord-440bf5b228934c0cb342e6f067dccbc3
Source dataset
uspto-grants-1982_09
Patent number
US04349684

Reaction notes

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