Hydrochloric Acid → HCID 22761079, compound

HRID 1704097Notes

Reaction equation

HRID 1704097 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[OH-].[K+].[I-].[K+].Cl[CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25]([OH:27])=[O:26])=[CH:20][CH:19]=1.Cl>C(O)C.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][C:25]([OH:27])=[O:26])=[CH:20][CH:19]=2)=[CH:4][CH:3]=1

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 46844-ChlorophenolHCID 4875Potassium IodideHCID 14797Potassium HydroxideHCID 10633141HCID 10633141, compound

Product 1

HCID 22761079HCID 22761079, compoundYield 73.6%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2.58 g of p-chlorophenol in 25 ml of ethanol is added 2.64 g of 85% potassium hydroxide solution, 3.6 g of potassium iodide and 4.6 g of [p-(3-chloropropoxy)phenyl]acetic acid. The mixture is refluxed for 18 hours, diluted with water, acidified with concentrated HCl and filtered to give 4.74 g of crystals. Recrystallization from acetic acid-water gives 3.85 g of white crystals, mp slowly melts 131°-150° C.

Workup

  1. temperatureThe mixture is refluxed for 18 hours
  2. filtrationfiltered

Sources & evidence

ORD record
ord-4a5c5d5676af485191d594dd5304c42b
Source dataset
uspto-grants-1978_11
Patent number
US04125732

Reaction notes

Loading…