Potassium Iodide → HCID 54411517, compound

HRID 1704103Notes

Reaction equation

HRID 1704103 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[H-].[Na+].[I-].[K+].Br[CH:17]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][CH2:31][O:32][C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=2)=[CH:24][CH:23]=1)[C:18]([O:20]C)=[O:19].O1CCC[CH2:41]1>CN(C)P(N(C)C)(N(C)C)=O>[Cl:39][C:36]1[CH:35]=[CH:34][C:33]([O:32][CH2:31][CH2:30][CH2:29][O:28][C:25]2[CH:26]=[CH:27][C:22]([CH2:17][C:18]([O:20][O:9][C:5]3[C:4]([CH3:41])=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:8]=[CH:7][CH:6]=3)=[O:19])=[CH:23][CH:24]=2)=[CH:38][CH:37]=1

Participants

7

Reactant 5

HCID 4875Potassium IodideHCID 73763-(Trifluoromethyl)phenolHCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 22761172HCID 22761172, compound

Product 1

HCID 54411517HCID 54411517, compound

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

As described in Example 30, a mixture of 3.4 g of m-trifluoromethylphenol, 0.755 g of 60% sodium hydride-oil dispersion, 3.5 g of potassium iodide, one ml of hexamethylphosphoramide and 7.9 g of methyl bromo{p-[3-(p-chlorophenoxy)propoxy]phenyl}acetate in 70 ml of tetrahydrofuran is refluxed for 18 hours and worked-up to give 10 g of oil. Purification gives 8.6 g of light amber oil.

Workup

  1. temperatureis refluxed for 18 hours

Sources & evidence

ORD record
ord-5d32361313ba4f86bd528e1e5bcb5c07
Source dataset
uspto-grants-1978_11
Patent number
US04125732

Reaction notes

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