反应详情

A mixture of 1-chloro-2,6-dinitrobenzene (30 grams), anhydrous potassium fluoride (35 grams), and dimethylformamide (50 ml.) is refluxed for twenty-four hours. The reaction mixture is poured into water (250 ml.) and extracted with ether (3 × 100 ml.). The combined ether extracts are dried with anhydrous sodium sulfate. Removal of the solvent leaves brown solid. Chromatography of the solid on silica gel with methylene chloride as the elutant gives a light yellow solid after recrystallization from pentane-methylene chloride. (20.30 grams, melting point 59°). Mass spectrum (70 ev) mol. ion 186 m/e.

1. temperatureis refluxed for twenty-four hours
2. extractionextracted with ether (3 × 100 ml.)
3. dry with materialThe combined ether extracts are dried with anhydrous sodium sulfate
4. customRemoval of the solvent
5. customleaves brown solid
6. customafter recrystallization from pentane-methylene chloride