Benzyl mercaptan → HCID 54428342, compound

HRID 1704273Notes

Reaction equation

HRID 1704273 reaction equation
[CH2:1]([SH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[Cl:11][C:12]([F:18])=[CH:13][CH2:14][CH2:15][CH2:16]Cl>CN(C)C=O>[Cl:11][C:12]([F:18])=[CH:13][CH2:14][CH2:15][CH2:16][S:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7509Benzyl mercaptanHCID 24758Sodium hydrideHCID 54317525HCID 54317525, compound

Product 1

HCID 54428342HCID 54428342, compoundYield 64.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.43 g of benzylmercaptan were mixed with 30 ml of N,N-dimethylformamide and then additioned with 0.7 g of NaH (55% in paraffin oil). Thereupon, at room temperature and under stirring, into this mixture were dripped 3 g of 1,5-dichloro-1-fluoro-pent-1-ene. The mixture was stirred for 5 hours at 25° C. After washing with water, extraction with ether, drying and evaporizing, there were obtained 3 g of raw product purified by chromatography in a column (cis-, trans- isomer mixture) and which had the following characteristics:

Workup

  1. stirringThe mixture was stirred for 5 hours at 25° C
  2. washAfter washing with water, extraction with ether
  3. customdrying

Sources & evidence

ORD record
ord-79cc5c02dce64de0a2c1fe98bece5c69
Source dataset
uspto-grants-1978_11
Patent number
US04126623

Reaction notes

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