反应详情

19.3 g (0.075 mol) of ethyl α-naphthylcarbamoylacetate are treated with a solution of hydroxylamine, prepared from 5.6 g (0.08 mol) of hydroxylamine hydrochloride and 3.68 g of sodium in 250 ml of methanol. After leaving the reactants in contact for 5 hours, the mixture is evaporated to dryness in vacuo, the residue is taken up in 400 ml of cold water, the solution is filtered over charcoal, and the product is precipitated cold with 3 N HCl, filtered off and washed with water. CRL 40,518 is obtained by recrystallisation from ethanol. Yield: 62% Melting point: 184°-186° C. (with decomposition)

1. customAfter leaving the reactants in contact for 5 hours
2. customthe mixture is evaporated to dryness in vacuo
3. filtrationthe solution is filtered over charcoal
4. customthe product is precipitated cold with 3 N HCl
5. filtrationfiltered off
6. washwashed with water
7. customCRL 40,518 is obtained by recrystallisation from ethanol