Potassium Acetate → HCID 10758857, compound

HRID 1707990Notes

Reaction equation

HRID 1707990 reaction equation
Br[CH2:2][C:3]1[CH:15]=[C:14]2[C:6]([C:7]3[CH:8]=[C:9]([Br:17])[CH:10]=[CH:11][C:12]=3[C:13]2=[O:16])=[CH:5][CH:4]=1.[C:18]([O-:21])(=[O:20])[CH3:19].[K+]>CN(C=O)C.C(OCC)(=O)C>[Br:17][C:9]1[CH:10]=[CH:11][C:12]2[C:13](=[O:16])[C:14]3[C:6]([C:7]=2[CH:8]=1)=[CH:5][CH:4]=[C:3]([CH2:2][O:20][C:18](=[O:21])[CH3:19])[CH:15]=3

Participants

5

Reactant 2

HCID 517044Potassium AcetateHCID 10665658HCID 10665658, compound

Product 1

HCID 10758857HCID 10758857, compoundYield 73.8%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
100 °C

Procedure

7-Bromomethyl-3-bromo-9-fluorenone (1.7 g) was suspended in DMF (25 ml). To this suspension was added potassium acetate (576 mg). The reaction mixture was stirred at 100° C. for one hour. It was then diluted with ethyl acetate, washed four times with water, twice with brine, dried and evaporated. The residue was chromatographed on silica gel using 2% ethyl acetate/methylene chloride which gave the desired product (1.18 g).

Workup

  1. washwashed four times with water
  2. dry with materialtwice with brine, dried
  3. customevaporated
  4. customThe residue was chromatographed on silica gel using 2% ethyl acetate/methylene chloride which

Sources & evidence

ORD record
ord-e6ef7618188247af8bd9e212aef50708
Source dataset
uspto-grants-1994_10
Patent number
US05356889

Reaction notes

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