反应详情

To 4N hydrochloric acid solution (46 ml) in ethyl acetate was added ethyl 1-(N-tert-butoxycarbonyl-N-methylamino)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (9.20 g) under ice-cooling and the mixture was stirred at the same condition for 2 hours. Diisopropyl ether (90 ml) was added to the mixture to give a solid. The solid was collected by filtration, and dried over phosphorus pentaoxide under reduced pressure to give ethyl 6,7,8-trifluoro-1-methylamino-1,4-dihydro -4-oxoquinoline-3-carboxylate hydrochloride(6.26 g).

1. temperaturecooling
2. customto give a solid
3. filtrationThe solid was collected by filtration
4. dry with materialdried over phosphorus pentaoxide under reduced pressure