Hydrochloric Acid → HCID 67849559, compound

HRID 1708540Notes

Reaction equation

HRID 1708540 reaction equation
[ClH:1].C(O[C:7]([N:9]([N:11]1[C:20]2[C:15](=[CH:16][C:17]([F:23])=[C:18]([F:22])[C:19]=2[F:21])[C:14](=[O:24])[C:13]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:12]1)C)=O)(C)(C)C.C(OC(C)C)(C)C>C(OCC)(=O)C>[ClH:1].[F:23][C:17]1[CH:16]=[C:15]2[C:20](=[C:19]([F:21])[C:18]=1[F:22])[N:11]([NH:9][CH3:7])[CH:12]=[C:13]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:14]2=[O:24]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 18959446ethyl 1-(N-tert-butoxycarbonyl-N-methylamino)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Product 1

HCID 67849559HCID 67849559, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 4N hydrochloric acid solution (46 ml) in ethyl acetate was added ethyl 1-(N-tert-butoxycarbonyl-N-methylamino)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (9.20 g) under ice-cooling and the mixture was stirred at the same condition for 2 hours. Diisopropyl ether (90 ml) was added to the mixture to give a solid. The solid was collected by filtration, and dried over phosphorus pentaoxide under reduced pressure to give ethyl 6,7,8-trifluoro-1-methylamino-1,4-dihydro -4-oxoquinoline-3-carboxylate hydrochloride(6.26 g).

Workup

  1. temperaturecooling
  2. customto give a solid
  3. filtrationThe solid was collected by filtration
  4. dry with materialdried over phosphorus pentaoxide under reduced pressure

Sources & evidence

ORD record
ord-f4ff6fd8e3514a62926fd3876b383af2
Source dataset
uspto-grants-1994_10
Patent number
US05359066

Reaction notes

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