反应详情

A mixture of 2 g of 6-(6-chlorohexoxy)-3-methoxy-4H-1-benzopyran-4-one, 1 g of sodium iodide, 0.6 g of potassium carbonate, and 1.4 g of 4-hydroxypiperidine was refluxed in butanone for 96 hours. The solvent was removed and the residue stirred with ethyl acetate and filtered. The solution was washed with water and then dried over sodium sulfate. The solvent was removed to give an oil which was chromatographed over silica gel to give 2 g of 6-[6-(4-hydroxypiperidinyl)hexoxy]-3-methoxy-4H-1-benzopyran-4-one which was converted to the hydrochloride salt by dissolving in ethyl acetate and adding 1 N ethereal HCL: mp 124°-125° C.

1. customThe solvent was removed
2. filtrationfiltered
3. washThe solution was washed with water
4. dry with materialdried over sodium sulfate
5. customThe solvent was removed
6. customto give an oil which
7. customwas chromatographed over silica gel