Triethylamine → (-) 4,4,5-Trimethyl 2-phenyl 1,3,2-dioxaphospholane

HRID 1710266Notes

Reaction equation

HRID 1710266 reaction equation
[CH3:1][C:2]([OH:7])([CH:4]([OH:6])[CH3:5])[CH3:3].Cl[P:9](Cl)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C.Cl.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:1][C:2]1([CH3:3])[CH:4]([CH3:5])[O:6][P:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:7]1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 11130Triethylamine hydrochlorideHCID 12573Phenyl phosphorus dichlorideHCID 953622-Methylbutane-2,3-diol

Product 1

HCID 13904591(-) 4,4,5-Trimethyl 2-phenyl 1,3,2-dioxaphospholane

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5 g of (+)2 methyl butane 2,3-diol, ##STR24## are mixed with 8.6 g of dichlorophenylphosphin at 0° C. under stirring in 250 ml of dry toluene, in an atmosphere. Then 10.2 g of triethylamine are added within a few minutes. After 1 hour of reaction triethylamine hydrochloride is formed; it is separated by filtration and the toluene solvent is vaporized.

Workup

  1. customis formed
  2. customit is separated by filtration

Sources & evidence

ORD record
ord-417867ea9d214e35b6c043ca5c25419c
Source dataset
uspto-grants-1990_08
Patent number
US04952740

Reaction notes

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