Hydrochloric Acid → HCID 67095380, compound

HRID 1710620Notes

Reaction equation

HRID 1710620 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([N:20]([S:22]([C:25]3[C:33]4[O:32][C:31]([F:35])([F:34])[O:30][C:29]=4[CH:28]=[CH:27][CH:26]=3)(=[O:24])=[O:23])[CH3:21])[CH:17]=[CH:16][C:15]=2[O:36][CH3:37])[CH2:10][CH2:9]1)=O)(C)(C)C.[H-].[Na+].CI.[ClH:42]>C(O)(C)C>[ClH:42].[CH3:21][N:20]([C:18]1[CH:17]=[CH:16][C:15]([O:36][CH3:37])=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:19]=1)[S:22]([C:25]1[C:33]2[O:32][C:31]([F:35])([F:34])[O:30][C:29]=2[CH:28]=[CH:27][CH:26]=1)(=[O:24])=[O:23]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 67094964HCID 67094964, compound

Product 1

HCID 67095380HCID 67095380, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The compound was prepared by reaction of 4-{5-[(2,2-difluorobenzo[1,3]dioxole-4-sulfonyl)-methyl-amino]-2-methoxy-phenyl}-piperazine-1-carboxylic acid tert-butyl ester with sodium hydride and methyliodide by analogy to Preparation Example 3, and subsequent deprotection of the tert.butoxycarbonyl group with hydrochloric acid in isopropanol.

Sources & evidence

ORD record
ord-64663eeca95249c5910d6baf89845f0b
Source dataset
uspto-grants-2010_09
Patent number
US07790727B2

Reaction notes

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