Benzene → Ethyl 2-[[7-[3-[4-(3-morpholin-4-ylprop-1-ynyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enoxy]-1-benzofuran-4-yl]oxy]acetate

HRID 171067Notes

Reaction equation

HRID 171067 reaction equation
[CH2:1]([C:2]#[CH:3])[N:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1.[CH3:52][CH2:53][N:54]([CH2:55][CH3:56])[CH2:57][CH3:58].[Cu:142][I:143].[I:10][c:11]1[cH:12][cH:13][c:14]([C:17](=[CH:18][CH2:19][O:20][c:21]2[cH:22][cH:23][c:24]([O:30][CH2:31][C:32](=[O:33])[O:34][CH2:35][CH3:36])[c:25]3[c:26]2[o:27][cH:28][cH:29]3)[c:37]2[cH:38][cH:39][c:40]([C:43]([F:44])([F:45])[F:46])[cH:41][cH:42]2)[cH:15][cH:16]1.[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1.[cH:59]1[cH:60][cH:61][cH:62][cH:63][cH:64]1.[cH:65]1[cH:66][cH:67][c:68]([P:69]([Pd:70]([P:71]([c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)([c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)[c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)([P:90]([c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)([c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)[c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[P:109]([c:110]2[cH:111][cH:112][cH:113][cH:114][cH:115]2)([c:116]2[cH:117][cH:118][cH:119][cH:120][cH:121]2)[c:122]2[cH:123][cH:124][cH:125][cH:126][cH:127]2)([c:128]2[cH:129][cH:130][cH:131][cH:132][cH:133]2)[c:134]2[cH:135][cH:136][cH:137][cH:138][cH:139]2)[cH:140][cH:141]1>>[CH2:1]([C:2]#[C:3][c:11]1[cH:12][cH:13][c:14]([C:17](=[CH:18][CH2:19][O:20][c:21]2[cH:22][cH:23][c:24]([O:30][CH2:31][C:32](=[O:33])[O:34][CH2:35][CH3:36])[c:25]3[c:26]2[o:27][cH:28][cH:29]3)[c:37]2[cH:38][cH:39][c:40]([C:43]([F:44])([F:45])[F:46])[cH:41][cH:42]2)[cH:15][cH:16]1)[N:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1

Participants

8

Reactant 7

HCID 241BenzeneHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 4129414-(2-Propyn-1-yl)morpholineHCID 90923842Ethyl 2-[[7-[3-(4-iodophenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-enoxy]-1-benzofuran-4-yl]oxy]acetateHCID 178420554HCID 178420554, compound

Product 1

HCID 91328347Ethyl 2-[[7-[3-[4-(3-morpholin-4-ylprop-1-ynyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enoxy]-1-benzofuran-4-yl]oxy]acetate

Sources & evidence

ORD record
ord-e3ab46743f1e4da7a2e6fb9c2ac143f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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