反应详情

To a solution of methyl 14-cyclohexyl-7-oxo-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (prepared as described in Example 9, Step 4) in 1,2-dichloroethane (0.11 M), was added 1.3 eq of (2-pyrrolidin-1-ylethyl)amine and 1.5 eq of HOAc, followed by 1.5 eq. of solid sodium triacetoxyborohydride. Sat. aq. NaHCO3 and CH2Cl2 were added after 2 h. The organic phase was separated, washed with brine, dried over Na2SO4, filtered and concentrated in vacuo giving the crude product, which was used without further purification; MS (ES+) m/z 502 (M+H)+.

1. customThe organic phase was separated
2. washwashed with brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo