Hydrochloric Acid → HCID 43219016, compound

HRID 1715306Notes

Reaction equation

HRID 1715306 reaction equation
Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18].Cl.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[CH3:20][O:19][C:17]([CH2:16][CH2:15][NH:14][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3])=[O:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 823854-(Chlorosulfonyl)benzoic acidHCID 192794Methyl beta-alanate

Product 1

HCID 43219016HCID 43219016, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

It is obtained by reacting 4-chlorosulfonyl-benzoic acid (1 eq) with H-βAla-OMe×HCl in CH2Cl2 using diisopropylethylamine (2 eq) as base. After 30 minutes at room temperature the reaction mixture is extracted with water and the organic layer is dried over Na2SO4. Removal of the solvent gives the title compound.

Workup

  1. customIt is obtained
  2. extractionAfter 30 minutes at room temperature the reaction mixture is extracted with water
  3. dry with materialthe organic layer is dried over Na2SO4
  4. customRemoval of the solvent

Sources & evidence

ORD record
ord-0ac2cd5667ec4cfbb11e2ca7df37bb19
Source dataset
uspto-grants-2010_09
Patent number
US07799812B2

Reaction notes

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