Water → HCID 68676006, compound

HRID 1716264Notes

Reaction equation

HRID 1716264 reaction equation
[C:1](Cl)(=[O:11])[C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[C:13]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][NH2:25])([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14].CC[N:28]([CH2:31][CH3:32])[CH2:29]C.[OH2:33]>CN(C=O)C>[C:16]([O:15][C:13](=[O:14])[NH:20][CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:1](=[O:11])[C:2]1[CH:10]=[CH:9][C:5]([C:6](=[O:7])[NH:20][CH2:21][CH2:22][CH2:32][CH2:31][NH:28][C:29]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:33])=[CH:4][CH:3]=1)([CH3:17])([CH3:18])[CH3:19]

Participants

6

Reactant 4

HCID 962WaterHCID 4351tert-butyl N-(4-aminobutyl)carbamateHCID 7488Terephthaloyl chlorideHCID 8471Triethylamine

Product 1

HCID 68676006HCID 68676006, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of terephthaloyl chloride (5.0 g, 0.0246 mol) in dry DMF (100 mL) is treated with N-Boc-1,4-diaminobutane (9.418 mL, 0.0493 mol) and stirred at RT for 30 minutes. Et3N (10.298 mL, 0.0739 mol) is added and stirring continues overnight. The resulting mixture is diluted with deionised water (100 mL) and after stirring at RT for 30 minutes, the mixture is filtered. The filter cake is washed with water and dried in vacuo (40° C.) to afford the title compound.

Workup

  1. stirringstirring
  2. waitcontinues overnight
  3. stirringafter stirring at RT for 30 minutes
  4. filtrationthe mixture is filtered
  5. washThe filter cake is washed with water
  6. customdried in vacuo (40° C.)

Sources & evidence

ORD record
ord-ed12763dc8e04a8bad22b4914b651077
Source dataset
uspto-grants-2010_09
Patent number
US07803804B2

Reaction notes

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