反应详情

To a solution of N,N-dimethylglycine hydrochloride (0.17 mg), triethylamine (0.17 ml) and HOBt (0.18 g) in dichloromethane (10 ml) was added WSC (0.23 g), and the mixture was stirred at room temperature for 20 min. 1-(4-Aminophenyl)-N-cyclopropyl-5-propyl-1H-1,2,3-triazole-4-carboxamide (0.29 g) obtained in Example 1d) was added to the reaction mixture, and the mixture was stirred at room temperature for 3 days. The reaction mixture was diluted with dichloromethane, and washed with aqueous sodium hydrogen carbonate solution. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by high performance liquid chromatography to give the title compound as a white powder (0.09 g, 24%).

1. stirringthe mixture was stirred at room temperature for 3 days
2. washwashed with aqueous sodium hydrogen carbonate solution
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by high performance liquid chromatography