Hydrochloric Acid → HCID 68514994, compound

HRID 1717239Notes

Reaction equation

HRID 1717239 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:32])[CH2:23][NH:24]C(=O)OC(C)(C)C)=[CH:17][CH:16]=3)[C:11]=2[CH2:12][CH2:13][CH3:14])=[O:6])[CH2:3][CH2:2]1.Cl>C(O)C.C(O)(C)C>[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:15]3[CH:16]=[CH:17][C:18]([NH:21][C:22](=[O:32])[CH2:23][NH2:24])=[CH:19][CH:20]=3)[C:11]=2[CH2:12][CH2:13][CH3:14])=[O:6])[CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86629792HCID 86629792, compound

Product 1

HCID 68514994HCID 68514994, compoundYield 108.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3776IsopropanolSolvent

Procedure

To a suspension of tert-butyl {2-[(4-{4-[(cyclopropylamino)carbonyl]-5-propyl-1H-1,2,3-triazol-1-yl}phenyl)amino]-2-oxoethyl}carbamate (0.76 g) obtained in Example 22 in ethanol (5 ml) was added 6N hydrochloric acid in isopropyl alcohol solution (6 ml) at room temperature, and the mixture was stirred for 2 hr. The solvent was evaporated under reduced pressure to give the title compound as a white powder (0.64 g, 100%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-abcea3c4ef8f4f948a10acfe9d5fea63
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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