反应详情

To a suspension of N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-(hydroxymethyl)-1H-1,2,3-triazole-4-carboxamide (0.10 g) obtained in Example 112 in THF (3 ml)—toluene (3 ml) were added 4-bromophenol (0.053 g), tributylphosphine (0.15 ml) and ADDP (0.15 g). The reaction mixture was stirred at room temperature for 15 min, the insoluble material was filtered off, and the solvent was evaporated. The residue was purified by silica gel column (hexane/ethyl acetate=1/2 to ethyl acetate). The resultant product was recrystallized from ethyl acetate/hexane to give the title compound as a colorless powder (0.14 g, 95%).

1. filtrationthe insoluble material was filtered off
2. customthe solvent was evaporated
3. customThe residue was purified by silica gel column (hexane/ethyl acetate=1/2 to ethyl acetate)
4. customThe resultant product was recrystallized from ethyl acetate/hexane