Chlorodifluoromethane → HCID 20185697, compound

HRID 1719598Notes

Reaction equation

HRID 1719598 reaction equation
[F:1][CH:2]([F:4])Cl.[NH2:5][C:6]1[N:11]=[C:10]([SH:12])[N:9]=[C:8]([O:13][CH3:14])[N:7]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[NH2:5][C:6]1[N:11]=[C:10]([S:12][CH:2]([F:4])[F:1])[N:9]=[C:8]([O:13][CH3:14])[N:7]=1

Participants

5

Reactant 3

HCID 6372ChlorodifluoromethaneHCID 11430Potassium CarbonateHCID 178494245HCID 178494245, compound

Product 1

HCID 20185697HCID 20185697, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

10.0 g of gaseous difluorochloromethane are introduced, during a period of 90 minutes at a temperature of 70° to 75° C., into a suspension of 5.0 g of 2-amino-4-mercapto-6-methoxy-1,3,5-triazine and 4.8 g of potassium carbonate in 100 ml of dimethylformamide. The reaction mixture is concentrated by evaporation, the residue is stirred up with water, and the solid precipitate is separated. The yield is 1.6 g of 2-amino-4-difluoromethylthio-6-methoxy-1,3,5-triazine, m.p. 146° to 150° C. (compound No. 1.14).

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. customthe solid precipitate is separated

Sources & evidence

ORD record
ord-c027ffab02d94b0eba59f0cc02ce9f61
Source dataset
uspto-grants-1985_09
Patent number
US04540782

Reaction notes

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