反应详情

A mixture of 1.8 g (14.7 mmoles)3-chlorolactic acid and 3.4 g p-chlorophenol in 15 ml 3.3 N sodium hydroxide was stirred under reflux for two hours. The mixture was cooled to room temperature and acidified to pH=3, with concentrated hydrochloric acid. The resulting white crystals were filtered and dissolved in hot water and the hot solution was adjusted to pH=1 with concentrated sulfuric acid. Upon cooling the product, 3-(p-chlorophenoxy)-lactic acid was collected as clear crystals, 0.7 g, m.p. 135° to 136° C.; Edelson, et al. Biochem Pharmacol 18, 2331 (1969) reported m.p. 137° to 138° C.

1. temperatureunder reflux for two hours
2. filtrationThe resulting white crystals were filtered
3. dissolutiondissolved in hot water
4. temperatureUpon cooling the product, 3-(p-chlorophenoxy)-lactic acid
5. customwas collected as clear crystals, 0.7 g, m.p. 135° to 136° C.