Nitromethane → HCID 53750430, compound

HRID 1720070Notes

Reaction equation

HRID 1720070 reaction equation
[CH2:1]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH:18]=O)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C([O-])(=O)C.[NH4+].[N+:25]([CH3:28])([O-:27])=[O:26]>>[C:3]1([CH2:2][CH2:1][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][CH:13]=[C:12]3[CH:18]=[CH:28][N+:25]([O-:27])=[O:26])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 6375NitromethaneHCID 517165Ammonium AcetateHCID 22419951HCID 22419951, compound

Product 1

HCID 53750430HCID 53750430, compound

Procedure

The aidehyde 5-phenethyl-3-formylindole (0.15 g, 0.6 mmol), nitromethane (0.9 ml) and ammonium acetate (0.05 g, 0.7 mmol) were heated gently under reflux for 0.5 h. On cooling, crystals slowly separated. Crystallization from methanol gave of 5-(2-phenylethyl)-3-(2-nitroethenyl)indole as crystals.

Workup

  1. temperatureunder reflux for 0.5 h
  2. temperatureOn cooling
  3. customcrystals slowly separated
  4. customCrystallization from methanol

Sources & evidence

ORD record
ord-0af00cb5f4664397a49ecca55153c728
Source dataset
uspto-grants-1996_04
Patent number
US05504101

Reaction notes

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