Hydrochloric Acid → HCID 22417953, compound

HRID 1720265Notes

Reaction equation

HRID 1720265 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:6]=[C:5]2[NH:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)=[CH:21][CH:20]=1.[C:33](OC(=O)C)(=[O:35])[CH3:34].C(N(CC)CC)C.[ClH:47]>CN(C1C=CN=CC=1)C.C(Cl)Cl>[ClH:47].[C:33]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[CH:6]=[C:5]2[NH:18][C:19]1[CH:20]=[CH:21][C:22]([O:25][CH2:26][CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)=[CH:23][CH:24]=1)(=[O:35])[CH3:34]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 22417777HCID 22417777, compound

Product 1

HCID 22417953HCID 22417953, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

This compound was prepared from the corresponding 6-amino-4-(p-cyclohexylmethoxyanilino)-2-phenylquinoline with acetic anhydride, DMAP, and triethylamine in methylene chloride, followed by treatment with HCl to form the hydrochloric salt.

Workup

  1. customto form the hydrochloric salt

Sources & evidence

ORD record
ord-a68a4544f4214677bfc5d50f5f2f777d
Source dataset
uspto-grants-1996_04
Patent number
US05506235

Reaction notes

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