Thioglycerol → HCID 10537793, compound

HRID 1720792Notes

Reaction equation

HRID 1720792 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH:7]=[CH2:8])([CH3:4])([CH3:3])[CH3:2].[SH:10][CH2:11][CH:12]([CH2:14][OH:15])[OH:13]>C(N(CC)CC)C.C(OCC)(=O)C>[C:1]([O:5][C:6](=[O:9])[CH2:7][CH2:8][S:10][CH2:11][CH:12]([OH:13])[CH2:14][OH:15])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 7291ThioglycerolHCID 15458tert-Butyl acrylate

Product 1

HCID 10537793HCID 10537793, compoundYield 93.2%

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Acrylic acid t-butyl ester (15 g) and thioglycerol (15 g) were mixed together in the absence of solvent. To the reaction mixture, one drop of triethylamine was added to cause an exothermic reaction, yielding a homogeneous reaction mixture, which was then diluted with ethyl acetate, washed with water and dried, followed by solvent concentration under reduced pressure, to yield the title compound (25.79 g, yield 93%) as a colorless oily substance.

Workup

  1. customan exothermic reaction
  2. customyielding a homogeneous reaction mixture, which
  3. washwashed with water
  4. customdried
  5. concentrationfollowed by solvent concentration under reduced pressure

Sources & evidence

ORD record
ord-f16d652878264832a3f4bbb2ed3a9fd7
Source dataset
uspto-grants-1996_04
Patent number
US05506267

Reaction notes

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