Hydrochloric Acid → 5-[[6-(5-fluoro-2,3-dihydroindole-1-carbonyl)pyrimidin-4-yl]amino]spiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-2'-one

HRID 172110Notes

Reaction equation

HRID 172110 reaction equation
[CH3:40][CH:41]([OH:42])[CH3:43].[Cl:20][c:21]1[cH:22][c:23]([C:27](=[O:28])[N:29]2[CH2:30][CH2:31][c:32]3[cH:33][c:34]([F:38])[cH:35][cH:36][c:37]32)[n:24][cH:25][n:26]1.[ClH:39].[NH2:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[CH2:7][C:6]1([CH2:5]2)[C:11](=[O:19])[NH:12][c:13]2[n:14][cH:15][cH:16][cH:17][c:18]21.[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[NH:1]([c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[CH2:7][C:6]1([CH2:5]2)[C:11](=[O:19])[NH:12][c:13]2[n:14][cH:15][cH:16][cH:17][c:18]21)[c:21]1[cH:22][c:23]([C:27](=[O:28])[N:29]2[CH2:30][CH2:31][c:32]3[cH:33][c:34]([F:38])[cH:35][cH:36][c:37]32)[n:24][cH:25][n:26]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 6228DimethylformamideHCID 58117506(6-Chloro-pyrimidin-4-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanoneHCID 591667225-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Product 1

HCID 498039415-[[6-(5-fluoro-2,3-dihydroindole-1-carbonyl)pyrimidin-4-yl]amino]spiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-2'-one

Sources & evidence

ORD record
ord-754cd8c926744b44b5b52b18992419b8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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