反应详情

A mixture consisting of one mole (149 g) of 4,5-dihydroxyphenylacetonitrile prepared in stage 1, two moles of potassium carbonate (276 g) and 2.2 moles (278.5 g) of benzyl chloride in 745 ml of dimethylformamide is heated to 105°-110° C. for approximately 30 minutes. At the end of the reaction, the reaction mixture is diluted with 2.5 kg of a mixture of ice and water, and is neutralized with hydrochloric acid while being briskly stirred. The expected product, which has precipitated, is filtered off, washed with water, and is again mixed into a paste with ethanol and then with isopropyl ether.

1. temperatureis heated to 105°-110° C. for approximately 30 minutes
2. customAt the end of the reaction
3. customThe expected product, which has precipitated
4. filtrationis filtered off
5. washwashed with water
6. additionis again mixed into a paste with ethanol