Chloroacetone → HCID 24755240, compound

HRID 1721351Notes

Reaction equation

HRID 1721351 reaction equation
[H-].[Na+].CO[C:5]1C=C[C:8]([SH:11])=[CH:7][CH:6]=1.Cl[CH2:13][C:14](=[O:16])[CH3:15].[CH2:17]1[CH2:21][O:20][CH2:19][CH2:18]1>>[CH2:13]([S:11][CH2:8][C:7]1[CH:18]=[CH:17][C:21]([O:20][CH3:19])=[CH:5][CH:6]=1)[C:14]([CH3:15])=[O:16]

Participants

5

Reactant 4

HCID 6571ChloroacetoneHCID 8028TetrahydrofuranHCID 127654-MethoxybenzenethiolHCID 24758Sodium hydride

Product 1

HCID 24755240HCID 24755240, compound

Procedure

0.165 Mol sodium hydride is added portionwise at 0° to a solution of 4-methoxy-thiophenol (0.15 mol) in 300 ml THF. After 1 hour chloracetone (0.165 mol) is added. The mixture is stirred overnight at room temperature. Thereafter the solvent is evaporated and the mixture is dissolved in CH2Cl2 and washed with 2 N Na2CO3. The organic phase is dried and the solvent is evaporated to yield the title a) compound which is used without further purification.

Workup

  1. customThereafter the solvent is evaporated
  2. dissolutionthe mixture is dissolved in CH2Cl2
  3. washwashed with 2 N Na2CO3
  4. customThe organic phase is dried
  5. customthe solvent is evaporated
  6. customto yield the title a) compound which
  7. customis used without further purification

Sources & evidence

ORD record
ord-8bb8c1da78e4457c899d1dbe41ae5470
Source dataset
uspto-grants-1996_04
Patent number
US05510353

Reaction notes

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