Propofol → HCID 53922406, compound

HRID 1721392Notes

Reaction equation

HRID 1721392 reaction equation
Cl[S:2]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])=[O:3].[CH:11]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH:20]([CH3:22])[CH3:21])[C:15]=1[OH:23])([CH3:13])[CH3:12]>>[CH:20]([C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([CH:11]([CH3:13])[CH3:12])[C:15]=1[O:23][S:2]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])=[O:3])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 4943PropofolHCID 12225100Ethyl (chlorosulfonyl)acetate

Product 1

HCID 53922406HCID 53922406, compound

Procedure

The general procedure of Example I(A) was followed to react ethyl chlorosulfonylacetate with 2,6-diisopropylphenol to give ethyl (2,6-diisopropylphenoxysulfonyl)acetate. The ethyl acetate derivative was hydrolyzed to 2,6-diisopropylphenoxysulfonyl acetic acid. The acetic acid derivative was reacted with dodecylamine and DCC according to Example I(B) to provide 2,6-diisopropylphenyl N-dodecylcarbamoylmethylsulfonate, mp 75°-78° C.

Sources & evidence

ORD record
ord-4fc15a7e65434d19b817e27ba0edd99a
Source dataset
uspto-grants-1996_04
Patent number
US05510379

Reaction notes

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