2-Chlorobenzaldehyde → HCID 20030102, compound

HRID 1721881Notes

Reaction equation

[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[NH2:10][C:11]1[N:16]([CH3:17])[C:15](=[O:18])[N:14]([CH3:19])[C:13](=[O:20])[CH:12]=1.[CH3:21][C:22]1[N:23]([CH:29]([CH3:40])[CH2:30][O:31][CH2:32][C:33](=O)[CH2:34][C:35]([O:37][CH3:38])=[O:36])[C:24]([CH3:28])=[C:25]([CH3:27])[N:26]=1>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]1[C:12]2[C:13](=[O:20])[N:14]([CH3:19])[C:15](=[O:18])[N:16]([CH3:17])[C:11]=2[NH:10][C:33]([CH2:32][O:31][CH2:30][CH:29]([N:23]2[C:24]([CH3:28])=[C:25]([CH3:27])[N:26]=[C:22]2[CH3:21])[CH3:40])=[C:34]1[C:35]([O:37][CH3:38])=[O:36]

Participants

Reactant 3

HCID 69962-Chlorobenzaldehyde

HCID 811526-Amino-1,3-dimethyluracil

HCID 20070366HCID 20070366, compound

Product 1

HCID 20030102HCID 20030102, compoundYield 5.2%

Procedure

The title compound (150 mg) was prepared from 2-chlorobenzaldehyde (747 mg), 6-amino-1,3-dimethyl-2,4-dioxopyrimidine (824 mg) and methyl 4-[2-(2,4,5-trimethylimidazol-1-yl)propoxyl]3-oxobutanoate (1.5 g) by the method of Example 1. M.p. 180°-182° C.

Sources & evidence

ORD record: ord-ee9924a21ea840498ce173c271e6a3c2
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04853392

Reaction notes

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