Tetrahydrofuran → HCID 20027312, compound

HRID 1722714Notes

Reaction equation

HRID 1722714 reaction equation
[CH2:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#N)=[CH:7][CH:6]=1)[C:2]#[CH:3].[Mg].Cl.[CH2:15]([N:17]([CH2:22][CH3:23])[CH2:18][CH2:19][CH2:20]Cl)[CH3:16].[O:24]1CCCC1>>[CH2:15]([N:17]([CH2:22][CH3:23])[CH2:18][CH2:19][CH2:20][C:9]([C:8]1[CH:11]=[CH:12][C:5]([NH:4][CH2:1][C:2]#[CH:3])=[CH:6][CH:7]=1)=[O:24])[CH3:16]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 145749Diethylaminopropyl chloride, hydrochlorideHCID 5462224MagnesiumHCID 10796999HCID 10796999, compound

Product 1

HCID 20027312HCID 20027312, compound

Procedure

4-(2-Propynylamino)benzonitrile, 5 g (0.032 mol), in tetrahydrofuran is treated with an excess of the Grignard reagent which is prepared from fresh magnesium and 3-diethylaminopropyl chloride hydrochloride, according to the procedure of Sodet, Comptes Rendus, 254, pp. 3105-3107 (1962), to afford the desired product.

Sources & evidence

ORD record
ord-8f3b034fb7e140618fa234dc619c5e3d
Source dataset
uspto-grants-1989_08
Patent number
US04857530

Reaction notes

Loading…