反应详情

A solution of 3.43 g of sodium bisulfite in 20 ml of water was added to 2.81 g of N-carbobenzoxy-L-leucinal, and the mixture was stirred under ice-cooling for 14 hours. To the reaction mixture were added a solution of 1.41 g of potassium cyanide in 50 ml of water and 200 ml of ethyl acetate, and the mixture was stirred at room temperature for 4 hours. The ethyl acetate layer was washed with a saturated sodium chloride aqueous solution, dried over magnesium sulfate, and concentrated under reduced pressure to obtain 2.54 g of 3-carbobenzoxyamino-2-hydroxy-5-methylhexanenitrile as a colorless oil.

1. temperaturecooling for 14 hours
2. stirringthe mixture was stirred at room temperature for 4 hours
3. washThe ethyl acetate layer was washed with a saturated sodium chloride aqueous solution
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated under reduced pressure