Ethanol → HCID 85590471, compound

HRID 1723171Notes

Reaction equation

HRID 1723171 reaction equation
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:6].[NH2:7][OH:8].C(=O)([O-])[O-].[Ba+2].[CH2:14](O)[CH3:15]>>[Cl:6][C:15]1[CH:14]=[CH:5][C:4]([CH:2]2[CH2:3][C:4](=[N:7][OH:8])[CH2:5][S:1]2)=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 1127TetrahydrothiopheneHCID 10563Barium CarbonateHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 85590471HCID 85590471, compound

Procedure

A mixture of the above tetrahydrothiophene (5.70 g, 27.0 mmol), hydroxylamine HCl (2.81 g, 40.0 mmol) and barium carbonate (5.60 g) in 70 ml of ethanol is heated under reflux overnight. The solid is filtered and washed with 250 ml of hot ethanol. The filtrate is stripped of solvent, and the residue is diluted with ether and ethyl acetate, washed with water and with brine, dried and stripped of solvent to give 2-(4-chlorophenyl)-4-oxotetrahydrothiophene oxime.

Workup

  1. temperatureis heated
  2. temperatureunder reflux overnight
  3. filtrationThe solid is filtered
  4. washwashed with 250 ml of hot ethanol
  5. additionthe residue is diluted with ether and ethyl acetate
  6. washwashed with water and with brine
  7. customdried

Sources & evidence

ORD record
ord-bd1212bfe27d471f853ea82fa60ab85f
Source dataset
uspto-grants-1989_08
Patent number
US04859699

Reaction notes

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