Dimethylformamide → HCID 15314442, compound

HRID 1723318Notes

Reaction equation

HRID 1723318 reaction equation
C1(=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[NH:3]N1.[H-].[Na+].[CH3:15]I.[CH3:17][N:18](C)[CH:19]=[O:20]>>[CH3:17][N:18]1[N:11]=[C:4]([O:3][CH3:15])[C:5]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:19]1=[O:20]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 2194012,3-Dihydro-1,4-phthalazinedione

Product 1

HCID 15314442HCID 15314442, compoundYield 78%

Procedure

2,3-Dihydrophthalazine-1,4-dione (0.02 mol) was added to a suspension of sodium hydride (0.04 mol; 50% solution in mineral oil) in anhydrous dimethylformamide (100 ml). To this was slowly added an excess amount of methyl iodide (0.05 mol). The mixture was stirred under reflux for 24 hours. The solvent was evaporated and the product purified by recrystallization from benzene. The purified product was obtained in a yield of 78 percent.

Workup

  1. temperatureunder reflux for 24 hours
  2. customThe solvent was evaporated
  3. customthe product purified by recrystallization from benzene
  4. customThe purified product was obtained in a yield of 78 percent

Sources & evidence

ORD record
ord-3b6fa1def6f345b5804cf41f4897ac1f
Source dataset
uspto-grants-1989_08
Patent number
US04861778

Reaction notes

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