Ethanol → HCID 14575222, compound

HRID 1723486Notes

Reaction equation

HRID 1723486 reaction equation
[F:1][C:2]1[C:16]([F:17])=[C:15]([F:18])[C:14]([F:19])=[C:13]([F:20])[C:3]=1[O:4][CH:5]1[CH2:11][CH:10]2[NH:12][CH:7]([CH2:8][CH2:9]2)[CH2:6]1.[N+]([NH:24][C:25](N)=[O:26])([O-])=O.C(O)C>CO.CC(O)C.C(O)CC>[NH2:24][C:25]([N:12]1[CH:10]2[CH2:9][CH2:8][CH:7]1[CH2:6][CH:5]([O:4][C:3]1[C:13]([F:20])=[C:14]([F:19])[C:15]([F:18])=[C:16]([F:17])[C:2]=1[F:1])[CH2:11]2)=[O:26]

Participants

7

Reactant 3

HCID 702EthanolHCID 62372NitroureaHCID 14575211HCID 14575211, compound

Product 1

HCID 14575222HCID 14575222, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolvent2×HCID 10311-PropanolSolventHCID 3776IsopropanolSolvent

Procedure

The reaction of 3-(2,3,4,5,6-pentafluorophenoxy)-8-azabicyclo[3.2.1]octane 5 and nitrourea in an alkanol (e.g. methanol, ethanol, 1-propanol, 2-propanol, and the like; methanol being preferred) at a temperature of from about 20° C. to about 100° C., preferably from about 50° C. to about 80° C., provides a means of a furnishing an 8-aminocarbonyl-3-(2,3,4,5,6-pentafluorophenoxy)-8-azabicyclo[3.2.1]octane 6.

Workup

  1. customof from about 20° C. to about 100° C.

Sources & evidence

ORD record
ord-4ceae09f6e6b4e4585323f3187bccb58
Source dataset
uspto-grants-1989_08
Patent number
US04861889

Reaction notes

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