Hydrochloric Acid → HCID 14146379, compound

HRID 1723518Notes

Reaction equation

HRID 1723518 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]2[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)=[CH:8][CH:7]=1.[CH2:23]([NH:25][CH2:26][CH3:27])[CH3:24].Cl>>[CH2:23]([N:25]([CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]2[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)=[CH:8][CH:7]=1)[CH2:26][CH3:27])[CH3:24]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8021DiethylamineHCID 14146365HCID 14146365, compound

Product 1

HCID 14146379HCID 14146379, compoundYield 24%

Procedure

The title compound was prepared as described in Example 28 starting with (F) of Example 28 (3.0 g, 9.8 mmol) and using diethylamine in place of dibutylamine to produce 0.81 g (24% yield) of the title compound as the HCl salt, mp 187°-188° C. IR(KBr): 3400, 1600 cm-1. MS: 367(MH+). 1H NMR (CD3OD): δ 8.22-6.99 (m, 10H), 4.21 (t, J=5.1 Hz, 2H), 3.34 (m, 6H), 2.33 (m, 2H), 1.42 (m, 6H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-2ced18da07e74159934b9ba0634a0d73
Source dataset
uspto-grants-1989_08
Patent number
US04861897

Reaction notes

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