反应详情

9.94 mg of L-tartaric acid was added to 4 ml of a solution of 1-(2-fluorophenyl)-3-(piperidin-4-yloxy)-1H-indazole in MeOH (concentration=10.3 mg/ml). The solution was placed under a stream of N2 gas until approximately 0.2 ml of solution was left. Approximately 0.75 ml of IPA (isopropyl alcohol) was then added and solution was returned to aforementioned gas stream for less than 1 minute. Precipitation was observed and the suspension was capped. The suspension was stirred overnight, and the solution had become a gel. Approximately 3 ml of acetone was added and precipitation was observed. A solid was recovered on a membrane filter using vacuum filtration.

1. waitwas left
2. waitsolution was returned to aforementioned gas stream for less than 1 minute
3. customPrecipitation
4. customthe suspension was capped
5. additionApproximately 3 ml of acetone was added
6. customprecipitation
7. customA solid was recovered on a membrane
8. filtrationfilter
9. filtrationvacuum filtration