Tetrahydrofuran → N,N-bis(4-methoxybenzyl)-6-(2-(6-methoxypyridin-3-ylamino)-5-((4-(methylsulfonyl)piperazin-1-yl)methyl)pyridin-3-yl)-2-methylpyrimidin-4-amine
Reaction equation
[CH2:64]1[O:65][CH2:66][CH2:67][CH2:68]1.[CH3:1][Si:2]([N-:3][Si:4]([CH3:5])([CH3:6])[CH3:7])([CH3:8])[CH3:9].[CH3:55][O:56][c:57]1[cH:58][cH:59][c:60]([NH2:63])[cH:61][n:62]1.[F:11][c:12]1[n:13][cH:14][c:15]([CH2:44][N:45]2[CH2:46][CH2:47][N:48]([S:51](=[O:52])(=[O:53])[CH3:54])[CH2:49][CH2:50]2)[cH:16][c:17]1-[c:18]1[cH:19][c:20]([N:25]([CH2:26][c:27]2[cH:28][cH:29][c:30]([O:33][CH3:34])[cH:31][cH:32]2)[CH2:35][c:36]2[cH:37][cH:38][c:39]([O:42][CH3:43])[cH:40][cH:41]2)[n:21][c:22]([CH3:24])[n:23]1.[Li+:10]>>[c:12]1([NH:63][c:60]2[cH:59][cH:58][c:57]([O:56][CH3:55])[n:62][cH:61]2)[n:13][cH:14][c:15]([CH2:44][N:45]2[CH2:46][CH2:47][N:48]([S:51](=[O:52])(=[O:53])[CH3:54])[CH2:49][CH2:50]2)[cH:16][c:17]1-[c:18]1[cH:19][c:20]([N:25]([CH2:26][c:27]2[cH:28][cH:29][c:30]([O:33][CH3:34])[cH:31][cH:32]2)[CH2:35][c:36]2[cH:37][cH:38][c:39]([O:42][CH3:43])[cH:40][cH:41]2)[n:21][c:22]([CH3:24])[n:23]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-0a1c26cc417c4d78b2950641c2f1b409
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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