Dimethylformamide → HCID 57561129, compound

HRID 1724857Notes

Reaction equation

Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:4][C:3]=1[NH2:18].[Cl-].[NH4+].[OH-].[NH4+].[CH3:23][N:24](C=O)C>O.[C-]#N.[Zn+2].[C-]#N.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.[Fe+2]>[NH2:18][C:3]1[CH:4]=[C:5]([C:8]2[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:6]=[N:7][C:2]=1[C:23]#[N:24]

Participants

Conditions

Temperature: 0 °C

Procedure

Heat a solution of 6′-chloro-3-trifluoromethyl-[2,3′]bipyridinyl-5′-ylamine (25 g, 0.091 mol; prepared essentially as described in PCT International Application Publication Number WO 03/062209, published on Jul. 31, 2003), zinc cyanide (6.75 g, 0.058 mol), pd2(dba)3 (2.63 g, 2.86 mmol), DPPF (3.16 g, 5.72 mmol) in DMF (250 mL) and water (2.5 mL), under a nitrogen atmosphere, at 120° C. for 1 hour. Cool the reaction to 0° C. and add a solution of saturated ammonium chloride (200 ml), water (200 mL) and concentrated ammonium hydroxide (50 mL). After stirring at 0° C. for 1 hour, filter the yellow precipitate, and wash with water (200 mL) and a 1:1 mixture of ether-hexane (200 mL). Dry the solid in air and then in a vacuum oven to give the title compound.

Workup

customprepared essentially
temperatureCool
customthe reaction to 0° C.
filtrationfilter the yellow precipitate
washwash with water (200 mL)
additiona 1:1 mixture of ether-hexane (200 mL)
customDry the solid in air

Sources & evidence

ORD record: ord-61213f4f575d4bc6bcc95a4283a3afa7
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07488740B2

Reaction notes

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