反应详情

Heat a mixture of 5-chloro-2-(3-methylpyridin-2-yl)-[1,8]naphthyridine (51 mg, 0.2 mmol), 2-amino-5-trifluoromethylpyrimidine (42.0 mg, 0.25 mmol), xantphos (11.6 mg, 0.02 mmol), Pd2(dba)3 (18.3 mg, 0.02 mmol) and Cs2CO3 (130 mg, 0.4 mmol) in dioxane (2.0 mL) at 100° C. for 20 hours. Cool the mixture, concentrate under vacuum, dilute with EtOAc/water (5.0 mL each), filter through celite, wash celite with EtOAc (2×5 mL) and dry the combined organic layers with MgSO4. Filter the dried extract and concentrate under vacuum to afford the crude product. Purify by column chromatography using EtOAc as eluent to afford the title compound as a yellow solid. 1H NMR (400 MHZ, DMSO-D6) δ 10.92 (s, 1H), 9.0 (m, 3H), 8.92 (d, 1H, J=1.8 Hz), 8.58 (d, 1H, J=1.0 Hz), 8.12 (m, 2H), 7.80(d, 1H, J=2.1 Hz), 7.41 (dd, 1H), 2.65 (s, 3H). MS=383.3 (M+H).

1. temperatureHeat
2. temperatureCool the mixture
3. concentrationconcentrate under vacuum
4. additiondilute with EtOAc/water (5.0 mL each)
5. filtrationfilter through celite
6. washwash celite with EtOAc (2×5 mL)
7. dry with materialdry the combined organic layers with MgSO4
8. filtrationFilter the dried
9. extractionextract
10. concentrationconcentrate under vacuum
11. customto afford the crude product
12. customPurify by column chromatography