反应详情

To a solution of 3,4-difluoro-phenol (10 g, 77 mmol) in N,N-dimethylformamide (50 mL) was added potassium carbonate (20 g, 145 mmol) and iodoethane (50 g, 320 mmol, Aldrich). The reaction mixture was heated at refluxing for 48 h. The crude was cooled to room temperature and filtered through a short pad of celite. The filtrate was concentrated and the residue was purified by chromatography (EtOAc:Hexanes=1:8) to give 4-ethoxy-1,2-difluoro-benzene as colorless oil (Yield 11 g, 90%).

1. temperatureThe reaction mixture was heated
2. temperatureat refluxing for 48 h
3. filtrationfiltered through a short pad of celite
4. concentrationThe filtrate was concentrated
5. customthe residue was purified by chromatography (EtOAc:Hexanes=1:8)