Pyrrolidine → HCID 86760822, compound

HRID 1728182Notes

Reaction equation

HRID 1728182 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]=O.[Cl:11][C:12]1[CH:20]=[C:19]2[C:15]([CH2:16][C:17](=[O:21])[NH:18]2)=[CH:14][CH:13]=1.N1CCCC1>CO>[Cl:11][C:12]1[CH:20]=[C:19]2[C:15](/[C:16](=[CH:4]/[C:3]3[CH:6]=[C:7]([Cl:10])[CH:8]=[CH:9][C:2]=3[Cl:1])/[C:17](=[O:21])[NH:18]2)=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 31268PyrrolidineHCID 807022,5-DichlorobenzaldehydeHCID 7363446-Chloro-1,3-dihydroindol-2-one

Product 1

HCID 86760822HCID 86760822, compoundYield 107.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a manner similar to the method described in Example 227b, 2,5-dichloro-benzaldehyde (5 g, 28.57 mmol) was reacted with 6-chlorooxindole (4.77 g, 28.57 mmol) and pyrrolidine (2.43 g, 34.3 mmol) in methanol to give title compound as yellow solid (10 g).

Sources & evidence

ORD record
ord-1ae94846b268466da8ef8466d2b827b5
Source dataset
uspto-grants-2009_02
Patent number
US07495007B2

Reaction notes

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