Methane → HCID 19017137, compound

HRID 1728274Notes

Reaction equation

HRID 1728274 reaction equation
[CH3:1][Si:2]([CH3:23])([CH3:22])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]=[CH:17][CH2:18][CH2:19][CH2:20][OH:21])=[CH:12][CH:11]=2)=[N:8][CH:9]=1.C>[Pd].C(OCC)(=O)C>[CH3:23][Si:2]([CH3:1])([CH3:22])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21])=[CH:12][CH:11]=2)=[N:8][CH:9]=1

Participants

5

Reactant 2

HCID 297MethaneHCID 543181965-Trimethylsilyloxy-2-(4-[5-hydroxy-1-pentenyl]phenyl)pyridine

Product 1

HCID 19017137HCID 19017137, compoundYield 93.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

5.4 g of 5-trimethylsilyloxy-2-(4-[5-hydroxy-1-pentenyl]phenyl)pyridine, 1 g of palladium on active charcoal (10 w/w %) and 50 ml of ethyl acetate were reacted in an analogous manner to Example 1(c) to give 5.1 g of 5-trimethylsilyloxy-2-(4-[5-hydroxy-1-pentyl]phenyl)pyridine.

Sources & evidence

ORD record
ord-f7448474334b45799f63380712f00ea3
Source dataset
uspto-grants-1994_07
Patent number
US05326497

Reaction notes

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