Potassium Carbonate → HCID 19017938, compound

HRID 1728369Notes

Reaction equation

HRID 1728369 reaction equation
[C:1]([O-:4])([O-:3])=[O:2].[K+].[K+].O[C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:19])[C:16]([CH3:18])=[CH2:17])=[CH:10][CH:9]=1>O1CCCC1>[C:16]([O:2][C:1]([O:4][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:19])[C:16]([CH3:18])=[CH2:17])=[CH:10][CH:9]=1)=[O:3])([CH3:18])([CH3:17])[CH3:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 29520Acrylanilide, 4'-hydroxy-2-methyl-

Product 1

HCID 19017938HCID 19017938, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

K2CO3 (30 g) is added to a solution of 20.0 g (0.112 tool) of N-(4-hydroxyphenyl)methacrylamide in tetrahydrofuran (THF). A solution of 27 g (0.124 tool) of di-tert-butyl pyrocarbonate (di-tert-butyl dicarbonate) in THF is then added at room temperature while stirring. The reaction is complete after a few hours. The reaction mixture is poured onto ice and extracted with ethyl acetate, the organic phase is dried and the solvent is distilled off. A white crystalline product is obtained which is recrystallized from diisopropyl ether.

Workup

  1. waitThe reaction is complete after a few hours
  2. additionThe reaction mixture is poured onto ice
  3. extractionextracted with ethyl acetate
  4. customthe organic phase is dried
  5. distillationthe solvent is distilled off
  6. customA white crystalline product is obtained which
  7. customis recrystallized from diisopropyl ether

Sources & evidence

ORD record
ord-35d6440d334542a29f5bdac0ddf26616
Source dataset
uspto-grants-1994_07
Patent number
US05326840

Reaction notes

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