Sodium hydride → HCID 131718539, compound

HRID 1728652Notes

Reaction equation

HRID 1728652 reaction equation
[ClH:1].[CH2:2]([N:6]1[CH2:11][CH2:10][C@@H:9]([C:12]2[CH:17]=[CH:16][C:15]([N:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C@H:8]([CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)[CH2:7]1)[CH2:3][CH2:4][CH3:5].[CH2:33](N1CCC(C2C=CC(N(C)C)=CC=2)C(CO)C1)CCC.[H-].[Na+].FC1C=CC(C(F)(F)F)=CC=1>CN(C=O)C>[ClH:1].[CH3:19][N:18]([CH3:20])[C:15]1[CH:16]=[CH:17][C:12]([C@@H:9]2[CH2:10][CH2:11][N:6]([CH2:2][CH:3]([CH3:33])[CH2:4][CH3:5])[CH2:7][C@H:8]2[CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:25][CH:24]=2)=[CH:13][CH:14]=1

Participants

6

Reactant 4

HCID 24758Sodium hydrideHCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 19014393HCID 19014393, compoundHCID 131718540HCID 131718540, compound

Product 1

HCID 131718539HCID 131718539, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Was prepared as described for compound (11) from the 1-(2-methylbutyl) analogue of compound (12) (2 g), NaH (0.32 g) and 4-fluorobenzotrifluoride (2.16 g) in DMF (100 ml). 3 g crude product was purified on a silica gel column identified as compound (13) by MS and 1H NMR. M.p. 237.2°-237.6° C.

Workup

  1. customWas prepared
  2. custom3 g crude product was purified on a silica gel column

Sources & evidence

ORD record
ord-6bbf6bf85764452ebf9755bfaea7968f
Source dataset
uspto-grants-1994_07
Patent number
US05328917

Reaction notes

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