Benzene, 1-fluoro-2-(trifluoromethyl)- → HCID 131718541, compound

HRID 1728653Notes

Reaction equation

HRID 1728653 reaction equation
[ClH:1].[CH2:2]([N:6]1[CH2:11][CH2:10][C@@H:9]([C:12]2[CH:17]=[CH:16][C:15]([N:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C@H:8]([CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26](C(F)(F)F)=[CH:25][CH:24]=2)[CH2:7]1)[CH2:3][CH2:4][CH3:5].C(N1CCC(C2C=CC(N(C)C)=CC=2)C(CO)C1)CCC.FC1C=CC=CC=1[C:61]([F:64])([F:63])[F:62].[H-].[Na+]>CN(C=O)C>[ClH:1].[CH2:2]([N:6]1[CH2:11][CH2:10][C@@H:9]([C:12]2[CH:13]=[CH:14][C:15]([N:18]([CH3:20])[CH3:19])=[CH:16][CH:17]=2)[C@H:8]([CH2:21][O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:61]([F:64])([F:63])[F:62])[CH2:7]1)[CH2:3][CH2:4][CH3:5]

Participants

6

Reactant 4

HCID 9807Benzene, 1-fluoro-2-(trifluoromethyl)-HCID 24758Sodium hydrideHCID 19014393HCID 19014393, compoundHCID 131718540HCID 131718540, compound

Product 1

HCID 131718541HCID 131718541, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Preparation as described for compound (11) using 1 g of compound (12), 2-fluorobenzotrifluoride (1.2 g) and NaH (0.174 g) in DMF (100 ml). The crude product was precipitated as the hydrochloride from acetone-ether giving 0.4 g of crystals. M.p. 213.9°-214.9° C.

Workup

  1. customPreparation
  2. customThe crude product was precipitated as the hydrochloride from acetone-ether giving 0.4 g of crystals

Sources & evidence

ORD record
ord-5949bc5685314dd785be0ce9cafc2cb5
Source dataset
uspto-grants-1994_07
Patent number
US05328917

Reaction notes

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