Iodoethane → HCID 131718547, compound

HRID 1728658Notes

Reaction equation

HRID 1728658 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:28])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][NH:13][CH2:12][C@H:11]2[CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:6][CH:5]=1.[CH2:29](I)[CH3:30].C([O-])([O-])=O.[K+].[K+]>C(O)C>[ClH:1].[CH3:2][N:3]([CH3:28])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][N:13]([CH2:29][CH3:30])[CH2:12][C@H:11]2[CH2:16][O:17][C:18]2[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 131718545HCID 131718545, compound

Product 1

HCID 131718547HCID 131718547, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

Was prepared from (41) (0.35 g) and ethyl iodide (0.4 g) in abs. ethanol (30 ml). heating to 60° C. for 8 h, and subsequently at room temperature for 48 h in the presence of K2CO3 (0.4 g). Purification as described for compound (7) gave a yield of 38% of (42). M.p. 225.8°-228.1° C.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-3c061b3b1e3f4e958ba19493ebcad6d5
Source dataset
uspto-grants-1994_07
Patent number
US05328917

Reaction notes

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