Pyridine → 1,8-Diazabicyclo(5.4.0)undec-7-ene

HRID 1729055Notes

Reaction equation

HRID 1729055 reaction equation
ClC([O-])=O.[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C1COCC1>[CH2:8]1[CH2:9][CH2:10][N:5]2[C:10](=[N:5][CH2:6][CH2:7][CH2:8]2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 1049PyridineHCID 21226386Carbonochloridate

Product 1

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compounds of Formula (I) wherein R1 is --SO2NHCO2R22 may be prepared by reacting an appropriate chloroformate with the sulfonamide (78) in pyridine or in the presence of DBU in THF to afford the desired compound (80), as outlined in Scheme 22. ##STR40##

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-36aa48806b0b4dea87813736aef8a950
Source dataset
uspto-grants-1994_07
Patent number
US05330987

Reaction notes

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