Hydrochloric Acid → HCID 19012411, compound

HRID 1729337Notes

Reaction equation

HRID 1729337 reaction equation
[BH4-].[Na+].[CH2:3]([C:7]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]#[N:27])=[CH:16][CH:15]=2)[C:11](=[O:28])[C:10]([CH:29]=[O:30])=[CH:9][CH:8]=1)[CH2:4][CH2:5][CH3:6].Cl>C(O)(C)C>[CH2:3]([C:7]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]#[N:27])=[CH:16][CH:15]=2)[C:11](=[O:28])[C:10]([CH2:29][OH:30])=[CH:9][CH:8]=1)[CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 19012335HCID 19012335, compound

Product 1

HCID 19012411HCID 19012411, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

15 mg of NaBH4 are added at 20° to a solution of 370 mg of 6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-3-formyl-1,2-dihydro-2-oxopyridine in 5 ml of isopropanol, with stirring. After further stirring (1 hour), dilute hydrochloric acid is added dropwise until the evolution of H2 has ceased, and the mixture is evaporated. 6-Butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-3-hydroxymethyl-1,2-dihydro-2-oxopyridine is obtained after conventional working-up.

Workup

  1. additionis added dropwise until the evolution of H2
  2. customthe mixture is evaporated

Sources & evidence

ORD record
ord-efbffdc2643b40a4a69a012b886132e4
Source dataset
uspto-grants-1994_07
Patent number
US05332750

Reaction notes

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