Phthalimide → HCID 21496162, compound

HRID 1730771Notes

Reaction equation

HRID 1730771 reaction equation
[CH2:1]([O:3][C:4]1[C:19]([CH:20]([CH3:22])[CH3:21])=[CH:18][C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([S:16][CH3:17])[CH:11]=2)=[O:9])=[C:6]([N:23]2[C:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[N:26][N:25]=[C:24]2[CH2:34]O)[CH:5]=1)[CH3:2].[C:36]1(=[O:46])[NH:40][C:39](=[O:41])[C:38]2=[CH:42][CH:43]=[CH:44][CH:45]=[C:37]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[CH2:1]([O:3][C:4]1[C:19]([CH:20]([CH3:21])[CH3:22])=[CH:18][C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([S:16][CH3:17])[CH:11]=2)=[O:9])=[C:6]([N:23]2[C:27]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[N:26][N:25]=[C:24]2[CH2:34][N:40]2[C:36](=[O:46])[C:37]3=[CH:45][CH:44]=[CH:43][CH:42]=[C:38]3[C:39]2=[O:41])[CH:5]=1)[CH3:2]

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21496175HCID 21496175, compound

Product 1

HCID 21496162HCID 21496162, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 3, a mixture of 4-ethoxy-5-isopropyl-3'-methylthio-2-[3-(hydroxymethyl)-5-phenyl-4H-1,2,4-triazol-4-yl]benzophenone, phthalimide and triphenylphosphine in tetrahydrofuran was treated with diethyl azodicarboxylate to give 4-ethoxy-5-isopropyl-3'-methylthio-2-[3-(phthalimidomethyl)-5-phenyl-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-b852235c9b964829b20ec95725c3b272
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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