Phthalimide → HCID 21496135, compound

HRID 1730772Notes

Reaction equation

HRID 1730772 reaction equation
[CH:1]([S:4]([C:7]1[CH:8]=[CH:9][C:10]([N:22]2[C:26]([CH2:27][CH2:28][CH3:29])=[N:25][N:24]=[C:23]2[CH2:30]O)=[C:11]([CH:21]=1)[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])=[O:13])(=[O:6])=[O:5])([CH3:3])[CH3:2].[C:32]1(=[O:42])[NH:36][C:35](=[O:37])[C:34]2=[CH:38][CH:39]=[CH:40][CH:41]=[C:33]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[CH:1]([S:4]([C:7]1[CH:8]=[CH:9][C:10]([N:22]2[C:26]([CH2:27][CH2:28][CH3:29])=[N:25][N:24]=[C:23]2[CH2:30][N:36]2[C:32](=[O:42])[C:33]3=[CH:41][CH:40]=[CH:39][CH:38]=[C:34]3[C:35]2=[O:37])=[C:11]([CH:21]=1)[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])=[O:13])(=[O:5])=[O:6])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21496130HCID 21496130, compound

Product 1

HCID 21496135HCID 21496135, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 3, a mixture of 5-isopropylsulfonyl-2'-fluoro-2-[3-(hydroxymethyl)-5-propyl-4H-1,2,4-triazol-4-yl]benzophenone, phthalimide and triphenylphosphine in tetrahydrofuran was treated with diethyl azodicarboxylate to give 5-isopropylsulfonyl-2'-fluoro-2-[3-(phthalimidomethyl)-5-propyl-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-32f4495aa5a14d0fa37848f57197e103
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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