Phthalimide → HCID 21496166, compound

HRID 1730774Notes

Reaction equation

HRID 1730774 reaction equation
[CH:1]([NH:3][C:4]1[C:9]([C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[O:11])=[C:8]([N:19]2[C:23]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[N:22][N:21]=[C:20]2[CH2:31]O)[CH:7]=[CH:6][CH:5]=1)=[O:2].[C:33]1(=[O:43])[NH:37][C:36](=[O:38])[C:35]2=[CH:39][CH:40]=[CH:41][CH:42]=[C:34]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[CH:1]([NH:3][C:4]1[C:9]([C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[O:11])=[C:8]([N:19]2[C:23]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[N:22][N:21]=[C:20]2[CH2:31][N:37]2[C:36](=[O:38])[C:35]3=[CH:39][CH:40]=[CH:41][CH:42]=[C:34]3[C:33]2=[O:43])[CH:7]=[CH:6][CH:5]=1)=[O:2]

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21496169HCID 21496169, compound

Product 1

HCID 21496166HCID 21496166, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 3, a mixture of 6-formamido-2'-chloro-2-[3-(hydroxymethyl)-5-benzyl-4H-1,2,4-triazol-4-yl]benzophenone, phthalimide and triphenylphosphine in tetrahydrofuran was treated with diethyl azodicarboxylate to give 6-formamido-2'-chloro-2-[3-(phthalimidomethyl)-5-benzyl-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-5bc4dc83488249bab08534ef72820925
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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